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M-Spike Explained: What Monoclonal (M) Proteins Mean for Myeloma
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myeloma protein M Protein; monoclonal protein, hallmark of plasma cell dyscrasias, multiple myeloma
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How does the M-spike correlate to the amount of myeloma protein in the body?
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Monoclonal gammopathy of undetermined significance (MGUS) is diagnosed based on the following criteria: 1. Presence of a monoclonal protein (M protein): Detected in the blood at a concentration of less than 3 g/dL. 2. Bone marrow plasma cells: Less than 10% of the bone marrow cells are plasma cells. 3. Absence of end-organ damage: No evidence of damage that could be attributed to the plasma cell proliferative disorder, such as: - Hypercalcemia - Renal insufficiency - Anemia - Bone lesions Additi
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