May 29, 2024 · Transthyretin amyloid cardiomyopathy (ATTR-CM) is an underdiagnosed and potentially fatal disease of the heart muscle. As it progresses, the heart can become unable to adequately …

A big problem in ATTR-CM is the buildup of amyloid proteins in the heart. New treatments aim to remove these proteins, which could help your heart work better and ease symptoms.

Jan 24, 2025 · Takeaways Transthyretin cardiac amyloidosis (ATTR-CM) is a potentially deadly form of heart disease. It causes your heart muscle to stiffen so that it becomes less able to pump blood …

Jun 26, 2025 · ATTR-CM (transthyretin amyloid cardiomyopathy) is a rare condition that causes a range of vague symptoms, including shortness of breath. If left untreated, it can progress to heart failure.

Apr 8, 2025 · Transthyretin amyloid cardiomyopathy (ATTR-CM) is a type of heart disease that happens when an abnormal protein called amyloid builds up in the heart. Because the symptoms can look …

Dec 6, 2025 · Cardiac Manifestations of ATTR-CM The infiltration of amyloid fibrils into the heart muscle walls causes the organ to become abnormally thick and rigid. This leads to restrictive …

Dec 3, 2025 · A heart condition that builds amyloid proteins in your cardiac muscle, ATTR-CM is known to stiffen the heart over time. And with that stiffening, all sorts of symptoms can arise. Even more, if …

In ATTR-CM, amyloid deposits accumulate in the cardiac tissue,1 making the myocardium stiff and rigid and eventually affecting the heart’s mechanical function.3 Patients commonly present with signs of …

Apr 27, 2023 · ATTR-CM typically presents with clinical signs and symptoms of progressive congestive heart failure. In addition, they often have cardiac arrhythmia and conduction system disease, which …

Mar 3, 2025 · The Good Brigade/Getty Images Transthyretin amyloid cardiomyopathy, or ATTR-CM, is an underdiagnosed heart condition with symptoms that mimic other conditions. Here’s how to …