Rethinking mRNA vaccines: Liver targeting can suppress immunity, while muscle boosts it

A new study by researchers at the Icahn School of Medicine at Mount Sinai overturns a longstanding assumption about how mRNA ...
Frontiers

mRNA Design, Manufacturing, Delivery, and Applications in Medicine

In vitro transcribed mRNA has lived up to its potential as a game-changing disruptive vaccine modality during the COVID-19 ...
GEN - Genetic Engineering and Biotechnology News

‘Type’ Casting: Flagship-Founded Serif Modifying DNA into New Therapy Class

Serif Biomedicines has emerged from stealth mode to continue developing “modified DNA,” a new class of therapeutics designed ...
eLife

Bivalent mRNA booster encoding virus-like particles elicits potent polyclass receptor-binding domain antibodies in pre-vaccinated mice

Bivalent EABR mRNA boosters broaden neutralizing responses to Omicron subvariants by promoting diverse receptor-binding domain epitope targeting, although antibody responses remain partially shaped by ...