BH3-only proteins (e.g. BID, BIM and PUMA) promote MOM integration of BAX/BAK, leading to MOMP, which typically commits the cell to death. The cytoprotective activity of BCL-XL is exerted through ...
PD-1 has unique properties relative to those of CTLA-4 (CD152), the other major negative coreceptor expressed on T cells. CTLA-4 has both cell-intrinsic activities (on effector cells) and ...
Researchers have found a switch that regulates the activity of HNF1A, a gene that causes diabetes. The study highlights potential new vulnerabilities in the disease and could lead to the development ...
David R. Amici, Daniel J. Ansel, Kyle A. Metz, Roger S. Smith, Claire M. Phoumyvong, Sitaram Gayatri, Tomasz Chamera, Stacey L. Edwards, Brendan P. O’Hara, Shashank ...
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