Adaptor protein (AP) complexes play central roles in intracellular vesicular trafficking by coupling cargo selection to vesicle formation. AP-4, an important member of the AP family, plays a key role ...

Particles (encircled in green) are spaced at a distance from the noise surrounding the nanobeads (purple), which would otherwise obscure them. Sample loss has been a persistent problem in cryo-EM, a ...

In order to expand access to cutting-edge research technology, the University of California, Santa Cruz, is welcoming institutions in the United States and abroad to use its powerful ...

A massive transmembrane complex, γ-secretase churns out the infamous peptides that can start a person on the path in Alzheimer’s disease. Aβ is produced when the secretase shaves three residues at a ...

Life science research relies upon advanced imaging technologies for detailed insights into the structure and function of organs, tissues, cells, and sub-cellular molecules. High-resolution 3D images ...