Methamphetamine doesn't just spike levels of the pleasure-inducing hormone dopamine in the reward pathways of the brain—it also provokes damaging brain inflammation through similar mechanisms. Meth is ...

Mount Sinai researchers, in collaboration with scientists at The Rockefeller University, have uncovered a mechanism in the brain that allows cocaine and morphine to take over natural reward processing ...

India, March 29 -- A large share of the inherited risk for substance use disorders may stem from genes that influence broader brain functions-such as how people respond to rewards, control impulses, ...

Researchers report October 25 in the journal Neuron that cocaine addiction disrupts the dopamine neurons that govern how we perceive and learn from rewards. Though people with cocaine addiction have ...

Implications for addiction treatment in humans The study helps to confirm that our gut, via the vagus nerve, plays a direct and essential role in how we experience reward and motivation. However, ...

New research may help explain why drug treatments for addiction and depression don't work for some patients. The conditions are linked to reward and aversion responses in the brain. Working in mice, ...

Mount Sinai researchers, in collaboration with scientists at The Rockefeller University, have uncovered a mechanism in the brain that allows cocaine and morphine to take over natural reward processing ...