Around half of the genome is made up of transposable elements or 'jumping genes' that derive from ancient viral integrations. They persist in various states of decay like an old fashioned 'pull your ...

Long interspersed element-1 (LINE-1 or L1) amplifies via retrotransposition. Active L1s encode 2 proteins (ORF1p and ORF2p) that bind their encoding transcript to promote retrotransposition in cis .

Long interspersed element 1 (LINE-1 or L1) retrotransposons compose 17% of the human genome. Active L1 elements are capable of replicative transposition (mobilization) and can act as drivers of ...

In a new SLAS Discovery auto-commentary, two authors of an article recently published in eLife ("LINE-1 Protein Localization and Functional Dynamics During the Cell ...

Retrotransposons are pivotal in human genome evolution, driving structural variation and regulatory innovation while influencing health and disease.

Long Interspersed Nuclear Element-1 (LINE-1 or L1) is the only active, self-copying genetic element in the human genome—comprising about 17% of the genome. It is commonly called a "jumping gene" or ...

Controlling the ability of retrotransposons to replicate and reinsert within the genome is important for maintaining the integrity of genetic information. For the first time, it has been shown that ...