Life's instructions are written in DNA, but it is the enzyme RNA polymerase II (Pol II) that reads the script, transcribing RNA in eukaryotic cells and eventually giving rise to proteins. Scientists ...

The paradoxical involvement of RNA-mediated gene silencing in the maintenance of some DNA silencing is bridged in Arabidopsis by an RNA polymerase that acts as a liaison between both pathways, ...

Researchers at the Department of Energy's SLAC National Accelerator Laboratory have uncovered new insights into the fundamental mechanisms of RNA polymerase II (Pol II), the protein responsible for ...

Originally isolated from soil microbes, “anthracyclines rapidly made their way to the clinic and are still one of the most effective compounds we have today,” explained Dr. Matthew Wooten, a ...

For all its mysteries, cancer can be boiled down to a disease caused by cell division gone haywire. But what determines the rate at which cancer cells can grow? They need cell building materials—amino ...

The transcription of ribosomal RNA by RNA Polymerase I (Pol I) is an essential step for cells to grow and thus is considered a therapeutic target for cancer treatment.

Researchers at the Johns Hopkins Kimmel Cancer Center and Department of Radiation Oncology and Molecular Radiation Sciences uncovered a new tumor-suppressive response that could lead to novel ...

The discovery shows that the production of ribosomal RNA (rRNA) is connected to how cells manage RNA splicing (a process that edits RNA). In studies of cancer cell lines using drugs that block rRNA ...

Thanks to a first-of-its-kind platform, we are starting to understand how the molecular engine responsible for transcription in mammals controls its speed. A team of researchers from The Rockefeller ...