Validated, tissue-specific library enables customisable and controllable liver-targeted gene expression with high specificity and minimal off-target activity in muscle tissue ...

In gene therapy, promoters act as vital “on/off” switches, dictating whether a therapeutic gene is active and to what extent. While delivery vehicles such as adeno-associated viruses (AAVs) can bring ...

Researchers say the deep learning model may help to create leads for new cancer diagnostics, patient stratification, and future therapies.

DNA sequences that regulate expression of the insulin gene are located within a region spanning ~400 bp that flank the transcription start site. This region, the insulin promoter, contains a number of ...

Over the past two decades, researchers have learned that DNA inside the cell nucleus naturally folds into a network of ...

Using single-cell epigenomic profiling of immune cells from 110 individuals, researchers show that genetic variation and ...