Oocyte maturation encompasses a series of coordinated nuclear and cytoplasmic events that prepare the female gamete for successful fertilisation and early embryonic development. In mammals, the ...

Oocyte maturation in vertebrates encompasses the transition from a growth-arrested germ cell to a fertilisation-competent egg through a tightly regulated sequence of meiotic events. Fully grown ...

The maturation process of oocytes remains paused for several years. Researchers from Konstanz and Göttingen have now found out which protein ensures this state is maintained over such a long period.

Age may influence an a human egg cell's ability to process gene products essential for the last steps of its development. The final maturation stage is critical for reproduction because it provides ...

Mechanistic model for MTOC maturation in GV oocytes. The MTOC (grey) activates near the oocyte cortex, which requires recruitment of CKAP5 and TACC3. After activation, MTOC migrates to the nuclear ...

The accumulation of misfolded or damaged proteins in long-lived, non-dividing cells like neurons are linked to neurodegenerative diseases like Alzheimer's. A study now finds that the build-up of these ...

Jo Wan-gyu, former president of Seoul National University who pioneered the principles of mammalian oocyte maturation and ...

Obesity is increasingly recognized as a major factor contributing to female reproductive dysfunction and declining fertility.

Age may adversely affect women's fertility by impairing levels of RNA molecules which in turn alter the function of genes involved in key biological pathways during the final maturation stage of a ...

Oocytes are immature egg cells that develop in almost all female mammals before birth. The propagation of future generations depends on this finite reserve of cells surviving for many years without ...