Flow cytometry, invented in the 1950s, uses antibodies linked to fluorescent probes to detect cell surface and intracellular proteins. Although able to achieve single-cell sensitivity, the method is ...

Many advances in medicine and drug development were possible owing to flow cytometry, a single-cell analysis technique that analyzes cells using the emitted fluorescence of their chemical tags while ...

This article will review flow cytometry to help readers understand the challenges faced when increasing flow cytometer SNR (signal-to-noise ratio). Quick review: What is flow cytometry? Flow cytometry ...

What motivated you to develop the ACE technique? One of the limitations of mass cytometry is its low sensitivity. To reach the detection limit, the target needs multiple copies of the antibody tag ...

Around the same time, Mack Fulwyler, an engineer working at Los Alamos National Laboratory, needed to separate particles, so he drew on existing techniques to create droplets to separate cells from a ...