Polβ-dependent DNA demethylation is essential for neuronal development. During neuronal development, DNA demethylation at enhancer regions is required to activate gene expression. In the absence of ...

Duke researchers find a surprising genetic source of lethal mutations in fruit flies, with possible implications for conservation and health Scientists have puzzled for decades over a basic ...

A technician inspects through a microscope a semen sample at a human sperm bank inside a hospital in Hefei, Anhui province, China February 21, 2019. Picture taken February 21, 2019. REUTERS/Stringer ...

Groundbreaking research shows that as men age, harmful genetic mutations in sperm become more common—not just from random chance, but because some are naturally favored. Advanced sequencing revealed ...

This voice experience is generated by AI. Learn more. This voice experience is generated by AI. Learn more. Genes and their variants interact in complex ways, so even “harmful” mutations can sometimes ...

For decades, the dream of fixing harmful mutations in mitochondrial DNA felt out of reach. Scientists have long known these mutations cause serious diseases that pass down only through mothers. They ...

Some genetic mutations that are expected to completely stop a gene from working surprisingly cause only mild or even no symptoms. Researchers in previous studies have discovered one reason why: cells ...

Cancer begins when mutations in specific genes override the body’s built-in controls on cell division, allowing rogue cells to multiply without restraint. Decades of research have traced this process ...

Between any two people, there are likely to be at least 10 million differences in the genetic sequence that makes up their DNA. Most of these differences don't alter the way cells behave or cause ...

New research published in Molecular Neurodegeneration has revealed that mutations in three genes known to cause familial Alzheimer’s disease can predict when symptoms will begin. By analyzing how ...