Researchers have discovered how cells activate a last-resort DNA repair system when severe damage strikes. When genetic ...

Rare inherited genetic variants significantly increase familial lung cancer risk, offering new targets for early detection.

DNA Repair Pathways in Clinical Practice: Lessons From Pediatric Cancer Susceptibility Syndromes. If you have the appropriate software installed, you can download article citation data to the citation ...

The researchers focused on Fanconi anemia, a rare inherited disorder characterized by a failure to repair specific types of DNA damage. In this condition, the two strands of DNA literally become stuck ...

A new study published today in Science Translational Medicine by researchers at The University of Texas MD Anderson Cancer ...

Alcohol consumption leads to the formation of a toxic compound called acetaldehyde, which damages DNA. A research team from IOCB Prague has now described in detail how cells repair this damaged ...

A new study published in Science Translational Medicine by researchers at The University of Texas MD Anderson Cancer Center ...

Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...

New research reveals that triggering a cell’s DNA damage response could be a promising avenue for developing novel treatments against several rare but devastating viruses for which no antiviral ...