DNA interstrand crosslinks (ICLs) are highly cytotoxic lesions formed by covalent bonding between opposite DNA strands, obstructing essential processes such as replication and transcription. Repair of ...
A single molecule of DNA (not directly visible) is captured using microscopic beads (the large circles). Each of the red, green or yellow dots moving between the beads represent a FANCD2I-FANCI ...
DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within ...
An elegant collaboration between researchers in the UK's two core-funded Medical Research Council Research Institutes, the Laboratory of Medical Sciences (LMS) in London and the Laboratory of ...
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