Methodological developments in biomedical research are currently moving towards single-cell approaches. This allows for a much better spatial and functional characterization of, for example, the ...

Biomedical research typically follows a familiar path: developing treatments that block, enhance or mutate certain signaling pathways, genes or proteins to change the function of different cells in ...

Human cells are organized across a spatial hierarchy of components, ranging from small protein complexes at the scale of nanometres to large condensates, compartments and organelles at the scale of ...

Taking images of tiny structures within cells is tricky business. One technique, cryogenic electron tomography (cryoET), shoots electrons through a frozen sample. The images formed by the electrons ...

Both images show individual red blood cells. The one on the right, produced by STED, more clearly shows the Piezo1 proteins (in green), which are a mechanical calcium channel and play a crucial role ...