Cancer cells carry thousands of mutations, but not all mutations are created equal. Some make tumors highly visible to the ...

Study results indicate that mutation strength may shape both tumor–immune system interactions and immunotherapy response.

Researchers have created the first complete map showing how hundreds of mutations in a key cancer gene affect tumor growth.

Scientists have created a complete map showing how hundreds of possible mutations in a key cancer gene influence tumor growth. The study focused on CTNNB1, a gene that produces the protein β-catenin, ...

A new study headed by teams at the Wellcome Sanger Institute, EMBL’s European Bioinformatics Institute (EMBL-EBI), and Open Targets has indicated how mutations that cause cancer drug resistance fall ...

TP53 mutations are crucial in cancer development and treatment response, influenced by genetic and environmental factors. In CLL and AML, TP53 serves as a significant prognostic marker, affecting ...

The gene p53 acts as a tumor suppressor and often is called the ‘guardian of the genome.’ This gene is central to maintaining genomic stability, which prevents mutations from accumulating and leading ...

Scientists have created a complete map showing how hundreds of possible mutations in a key cancer gene influence tumour growth.

Cells from cancerous tumors can spread, or metastasize, throughout the body. Researchers have long sought to understand what determines where those cells will go and thrive in order to more ...

An experimental drug combination was able to effectively treat pancreatic cancer in mouse models without tumor resistance.