image: Tppp3+ tendon sheath progenitors expand at the heterotopic ossification (HO) induction site after Achilles tendon injury. a Schematic representation of HO induction, including complete Achilles ...

Musculoskeletal disorders are a primary cause of disability worldwide, especially in aging societies like Japan. As individuals age, reductions in muscle mass and physical activity weaken the body's ...

Proposed model for Regulation of BMP Activity by DDR2. After binding collagen, DDR2 alone or together with collagen-binding β1 integrins stabilizes YAP/TAZ nuclear accumulation. This is accomplished ...

We have identified a macrophage population "Mrep" that plays an essential role in muscle repair. However, in Fibrodysplasia ossificans progressiva (FOP), Mrep functions as a pathogenic cell that ...

In a new study published in Bone Research, a team of researchers from Johns Hopkins University and colleagues, using a combination of lineage tracing and single-cell RNA sequencing (scRNA-seq), has ...