The source of the autophagosome membrane, and the formation of the autophagosome remain the most important questions for understanding autophagy. Fundamentally, the process of autophagosome formation ...

Autophagy, from the Greek for 'self-eating', is an essential process that isolates and recycles cellular components under conditions of stress or when resources are limited. Scientists have now ...

image: Postdoctoral Researcher Tetsuya Kotani, Associate Professor Hitoshi Nakatogawa, Honorary Professor Yoshinori Ohsumi and colleagues at Tokyo Tech have analyzed the Atg protein Atg2, whose ...

Drs. Nobuo Noda (Director) and Tatsuro Maruyama (Researcher) et al. at the Institute of Microbial Chemistry (BIKAKEN, Tokyo, Japan) discovered that lipidated Atg8(1), the most famous factor that ...

Autophagy (“self-eating”) is the process through which parts of the cell are degraded in the lysosome. Elucidation of the key genes essential for autophagy — originally identified in yeast — has led ...

The autophagic pathway proceeds through several phases, including initiation (formation of a preautophagosomal structure leading to an isolation membrane, or phagophore), vesicle elongation, ...

Lysosomes contain hydrolytic enzymes which cause the degradation of the contents transported by the autophagosome. The resultant macronutrients are recycled for use in the cytosol during starvation.

Illustration of an autophagosome (light blue double-membrane to the right) engulfing cellular material. David S. Goodsell and Daniel Klionsky/RCSB PDB-101, CC BY-SA Don’t let the textbook diagram of a ...

Autophagy, from the Greek for 'self-eating', is an essential process that isolates and recycles cellular components under conditions of stress or when resources are limited. Cargoes such as misfolded ...