The mechanism for a critical but highly toxic antifungal is revealed in high resolution. Self-assembled Amphotericin B sponges rapidly extract sterols from cells. This atomic level understanding ...

Amphotericin B is a clinically vital antifungal drug, but it has high renal toxicity. The compound kills cells by forming sponge-like aggregates on the cell surface that remove molecules called ...

“People have been trying to make amphotericin non-toxic for more than seventy years,” says Martin D. Burke of the University of Illinois at Urbana-Champaign, who co-led the research with Chad M.

University of Illinois researchers synthesized a derivative of the antifungal drug Amphotericin B that is less toxic but maintains its fungicidal efficacy. Pictured, from left: Agnieszka Lewandowska, ...